Prolactin Blocks Oncogene Associated with Poor Prognosis in Breast Cancer
Researchers from the Kimmel Cancer Center at Jefferson have found a mechanism by which a hormone responsible for milk production blocks an oncogene that makes breast
cancer more aggressive.
Publishing in the journal Cancer Research,
the researchers discovered that prolactin, a pituitary hormone that
normally stimulates breast development and milk production, in fact
reduces levels of an oncogene called BCL6. The BCL6 protein has
previously been shown to play a role in poorly differentiated breast
cancer, which carries a poorer prognosis.
According
to Hallgeir Rui, M.D., Ph.D., a professor of Cancer Biology and Medical
Oncology at Jefferson Medical College of Thomas Jefferson University,
prolactin’s role in breast cancer is, to a large extent, carried out by
a protein pathway called Stat5. In breast cancer, the inactivation of
Stat5 is related to poorly differentiated breast cancer, and thus
poorer prognosis.
“We
found that prolactin will block expression of the BCL6 protein, and
showed that Stat5a, but not the very similar Stat5b variant, is
involved in this process as a mediator of prolactin,” said Dr. Rui. “We
think that prolactin plays an important role in preventing aggressive
breast cancers, and that there is a connection between the loss of
Stat5 and the increase of BCL6 in making breast cancer more aggressive.
Dr Rui and his laboratory investigated the phenomenon in several different breast cancer cell lines grown in the laboratory,
and also in mice and in human breast cancer samples.The relationship held up across all three.
Receptors
for prolactin are present on a majority of breast cancers. Prolactin
levels in blood are relatively unaffected by menopause, and breast
cancer patients across all age groups are exposed to the hormone. The
new findings may lead to better diagnostic tests for breast cancer, and
also the development of new treatments.
Media Only Contact:
Emily Shafer
Thomas Jefferson University Hospital
Phone: (215) 955-6300
Published: 2/3/2010