The Jefferson Familial Colorectal Cancer Registry is a multidisciplinary collaborative program based on a comprehensive strategy of reducing colorectal cancer through early detection. Detecting early-stage colorectal cancer increases survival rates and decreases the need for invasive and costly treatments such as surgery, chemotherapy and radiation therapy.

One recognized risk factor for colorectal cancer is family history. Hereditary and familial syndromes are estimated to account for between 6 to 20 percent of all colorectal cancers. Researchers at Jefferson University Hospital's Kimmel Cancer Center are studying the genes responsible for inherited forms of colon cancer and the genetic alterations responsible for sporadic colorectal cancer. They are developing new and novel approaches for identifying at-risk individuals and are searching for prognostic indicators in tumor specimens.

The registry collects lifestyle, medical and family information as well as blood and tissue samples that serve as a resource for translational research focusing on the prevention and early detection of colorectal cancer. Blood and tissue samples are evaluated for genetic markers related to colorectal cancer. Molecular diagnostic tests are being developed to study the predisposition of family members to colorectal cancer. The impact of genetic counseling and genetic testing is also under evaluation.

Individuals eligible for the Registry include:

• Those with familial adenomatous polyposis (FAP) or hereditary nonpolyposis colorectal cancer (HNPCC);
• Those who have developed colorectal cancer under the age of 55 years;
• Patients who have had adenomatous polyps removed prior to the age of 45 years;
• Patients with a close relative diagnosed with colorectal cancer under the age of 50 years;
• Individuals who have had more than one occurrence of colorectal cancer.

For more information on the Jefferson Familial Colorectal Cancer Registry, contact the registry staff at 215-955-1011.