Gallstones
What Are Gallstones?
Gallstones form when liquid stored in the gallbladder hardens into pieces of stone-like material. The liquid, called bile,
is used to help the body digest fats. Bile is made in the liver, then stored in the gallbladder until the body needs to digest
fat. At that time, the gallbladder contracts and pushes the bile into a tube-called a duct-that carries it to the small intestine,
where it helps with digestion.
Bile contains water, cholesterol, fats, bile salts, and bilirubin. Bile salts break up fat, and bilirubin gives bile and stool
a brownish color. If the liquid bile contains too much cholesterol, bile salts, or bilirubin, it can harden into stones.
The two types of gallstones are cholesterol stones and pigment stones. Cholesterol stones are usually yellow-green and are
made primarily of hardened cholesterol. They account for about 80 percent of gallstones. Pigment stones are small, dark stones
made of bilirubin. Gallstones can be as small as a grain of sand or as large as a golf ball. The gallbladder can develop just
one large stone, hundreds of tiny stones, or almost any combination.
The gallbladder and the ducts that carry bile and other digestive enzymes from the liver, gallbladder, and pancreas to the
small intestine are called the
biliary system.
Gallstones can block the normal flow of bile if they lodge in any of the ducts that carry bile from the liver to the small
intestine. That includes the hepatic ducts, which carry bile out of the liver; the cystic duct, which takes bile to and from
the gallbladder; and the common bile duct, which takes bile from the cystic and hepatic ducts to the small intestine. Bile
trapped in these ducts can cause inflammation in the gallbladder, the ducts, or, rarely, the liver. Other ducts open into
the common bile duct, including the pancreatic duct, which carries digestive enzymes out of the pancreas. If a gallstone blocks
the opening to that duct, digestive enzymes can become trapped in the pancreas and cause an extremely painful inflammation
called pancreatitis.
If any of these ducts remain blocked for a significant period of time, severe-possibly fatal-damage can occur, affecting the
gallbladder, liver, or pancreas. Warning signs of a serious problem are fever, jaundice, and persistent pain.
What Causes Gallstones?
Cholesterol Stones
Scientists believe cholesterol stones form when bile contains too much cholesterol, too much bilirubin, or not enough bile
salts, or when the gallbladder does not empty as it should for some other reason.
Pigment Stones
The cause of pigment stones is uncertain. They tend to develop in people who have cirrhosis, biliary tract infections, and
hereditary blood disorders such as sickle cell anemia.
Other Factors
It is believed that the mere presence of gallstones may cause more gallstones to develop. However, other factors that contribute
to gallstones have been identified, especially for cholesterol stones.
- Obesity. Obesity is a major risk factor for gallstones, especially in women. A large clinical study showed that being even
moderately overweight increases one's risk for developing gallstones. The most likely reason is that obesity tends to reduce
the amount of bile salts in bile, resulting in more cholesterol. Obesity also decreases gallbladder emptying.
- Estrogen. Excess estrogen from pregnancy, hormone replacement therapy, or birth control pills appears to increase cholesterol
levels in bile and decrease gallbladder movement, both of which can lead to gallstones.
- Ethnicity. Native Americans have a genetic predisposition to secrete high levels of cholesterol in bile. In fact, they have
the highest rates of gallstones in the United States. A majority of Native American men have gallstones by age 60. Among the
Pima Indians of Arizona, 70 percent of women have gallstones by age 30. Mexican-American men and women of all ages also have
high rates of gallstones.
- Gender. Women between 20 and 60 years of age are twice as likely to develop gallstones as men.
- Age. People over age 60 are more likely to develop gallstones than younger people.
- Cholesterol-lowering drugs. Drugs that lower cholesterol levels in blood actually increase the amount of cholesterol secreted
in bile. This in turn can increase the risk of gallstones.
- Diabetes. People with diabetes generally have high levels of fatty acids called triglycerides. These fatty acids increase
the risk of gallstones.
- Rapid weight loss. As the body metabolizes fat during rapid weight loss, it causes the liver to secrete extra cholesterol
into bile, which can cause gallstones.
- Fasting. Fasting decreases gallbladder movement, causing the bile to become overconcentrated with cholesterol, which can lead
to gallstones.
Who is at Risk for Gallstones?
- Women.
- People over age 60.
- Native Americans.
- Mexican-Americans.
- Overweight men and women.
- People who fast or lose a lot of weight quickly.
- Pregnant women, women on hormone therapy, and women who use birth control pills.
What Are the Symptoms?
Symptoms of gallstones are often called a gallstone "attack" because they occur suddenly. A typical attack can cause
- Steady, severe pain in the upper abdomen that increases rapidly and lasts from 30 minutes to several hours.
- Pain in the back between the shoulder blades.
- Pain under the right shoulder.
- Nausea or vomiting.
Gallstone attacks often follow fatty meals, and they may occur during the night. Other gallstone symptoms include
- Abdominal bloating.
- Recurring intolerance of fatty foods.
- Colic.
- Belching.
- Gas.
- Indigestion.
People who also have the following symptoms should see a doctor right away:
- Sweating.
- Chills.
- Low-grade fever.
- Yellowish color of the skin or whites of the eyes.
- Clay-colored stools.
Many people with gallstones have no symptoms. These patients are said to be asymptomatic, and these stones are called "silent
stones." They do not interfere in gallbladder, liver, or pancreas function and do not need treatment.
How Are Gallstones Diagnosed?
Many gallstones, especially silent stones, are discovered by accident during tests for other problems. But when gallstones
are suspected to be the cause of symptoms, the doctor is likely to do an ultrasound exam. Ultrasound uses sound waves to create
images of organs. Sound waves are sent toward the gallbladder through a handheld device that a technician glides over the
abdomen. The sound waves bounce off the gallbladder, liver, and other organs, and their echoes make electrical impulses that
create a picture of the organ on a video monitor. If stones are present, the sound waves will bounce off them, too, showing
their location.
Other tests used in diagnosis include
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Cholecystogram or cholescintigraphy. The patient is injected with a special iodine dye, and x-rays are taken of the gallbladder over a period of time. (Some people
swallow iodine pills the night before the x-ray.) The test shows the movement of the gallbladder and any obstruction of the
cystic duct.
-
Endoscopic retrograde cholangiopancreatography (ERCP). The patient swallows an endoscope-a long, flexible, lighted tube connected to a computer and TV monitor. The doctor guides
the endoscope through the stomach and into the small intestine. The doctor then injects a special dye that temporarily stains
the ducts in the biliary system. ERCP is used to locate stones in the ducts.
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Blood tests. Blood tests may be used to look for signs of infection, obstruction, pancreatitis, or jaundice.
Gallstone symptoms are similar to those of heart attack, appendicitis, ulcers, irritable bowel syndrome, hiatal hernia, pancreatitis,
and hepatitis. So accurate diagnosis is important.
What is the Treatment?
Surgery
Surgery to remove the gallbladder is the most common way to treat symptomatic gallstones. (Asymptomatic gallstones usually
do not need treatment.) Each year more than 500,000 Americans have gallbladder surgery. The surgery is called cholecystectomy.
The standard surgery is called laparoscopic cholecystectomy. For this operation, the surgeon makes several tiny incisions
in the abdomen and inserts surgical instruments and a miniature video camera into the abdomen. The camera sends a magnified
image from inside the body to a video monitor, giving the surgeon a closeup view of the organs and tissues. While watching
the monitor, the surgeon uses the instruments to carefully separate the gallbladder from the liver, ducts, and other structures.
Then the cystic duct is cut and the gallbladder removed through one of the small incisions.
Because the abdominal muscles are not cut during laparoscopic surgery, patients have less pain and fewer complications than
they would have had after surgery using a large incision across the abdomen. Recovery usually involves only one night in the
hospital, followed by several days of restricted activity at home.
If the surgeon discovers any obstacles to the laparoscopic procedure, such as infection or scarring from other operations,
the operating team may have to switch to open surgery. In some cases the obstacles are known before surgery, and an open surgery
is planned. It is called "open" surgery because the surgeon has to make a 5- to 8-inch incision in the abdomen to remove the
gallbladder. This is a major surgery and may require about a 2- to 7-day stay in the hospital and several more weeks at home
to recover. Open surgery is required in about 5 percent of gallbladder operations.
The most common complication in gallbladder surgery is injury to the bile ducts. An injured common bile duct can leak bile
and cause a painful and potentially dangerous infection. Mild injuries can sometimes be treated nonsurgically. Major injury,
however, is more serious and requires additional surgery.
If gallstones are in the bile ducts, the surgeon may use ERCP in removing them before or during the gallbladder surgery. Once
the endoscope is in the small intestine, the surgeon locates the affected bile duct. An instrument on the endoscope is used
to cut the duct, and the stone is captured in a tiny basket and removed with the endoscope. This two-step procedure is called
ERCP with endoscopic sphincterotomy.
Occasionally, a person who has had a cholecystectomy is diagnosed with a gallstone in the bile ducts weeks, months, or even
years after the surgery. The two-step ERCP procedure is usually successful in removing the stone.
Nonsurgical Treatment
Nonsurgical approaches are used only in special situations-such as when a patient's condition prevents using an anesthetic-and
only for cholesterol stones. Stones recur after nonsurgical treatment about half the time.
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Oral dissolution therapy. Drugs made from bile acid are used to dissolve the stones. The drugs, ursodiol (Actigall) and chenodiol (Chenix), work best
for small cholesterol stones. Months or years of treatment may be necessary before all the stones dissolve. Both drugs cause
mild diarrhea, and chenodiol may temporarily raise levels of blood cholesterol and the liver enzyme transaminase.
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Contact dissolution therapy. This experimental procedure involves injecting a drug directly into the gallbladder to dissolve stones. The drug-methyl tert
butyl-can dissolve some stones in 1 to 3 days, but it must be used very carefully because it is a flammable anesthetic that
can be toxic. The procedure is being tested in patients with symptomatic, noncalcified cholesterol stones.
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Extracorporeal shockwave lithotripsy (ESWL). This treatment uses shock waves to break up stones into tiny pieces that can pass through the bile ducts without causing
blockages. Attacks of biliary colic (intense pain) are common after treatment, and ESWL's success rate is not very high. Remaining
stones can sometimes be dissolved with medication.
Don't People Need Their Gallbladders?
Fortunately, the gallbladder is an organ that people can live without. Losing it won't even require a change in diet. Once
the gallbladder is removed, bile flows out of the liver through the hepatic ducts into the common bile duct and goes directly
into the small intestine, instead of being stored in the gallbladder. However, because the bile isn't stored in the gallbladder,
it flows into the small intestine more frequently, causing diarrhea in some people. Also, some studies suggest that removing
the gallbladder may cause higher blood cholesterol levels, so occasional cholesterol tests may be necessary.
Points to Remember
- Gallstones form when substances in the bile harden.
- Gallstones are common among women, Native Americans, Mexican-Americans, and people who are overweight.
- Gallstone attacks often occur after eating a fatty meal.
- Symptoms can mimic those of other problems, including heart attack, so accurate diagnosis is important.
- Gallstones can cause serious problems if they become trapped in the bile ducts.
- Laparoscopic surgery to remove the gallbladder is the most common treatment.
National Digestive Diseases Information Clearinghouse
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National Digestive Diseases Information Clearinghouse
The National Digestive Diseases Information Clearinghouse (NDDIC) is a service of the National Institute of Diabetes and Digestive
and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health under the U.S. Department of Health and
Human Services. Established in 1980, the clearinghouse provides information about digestive diseases to people with digestive
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distributes publications; and works closely with professional and patient organizations and Government agencies to coordinate
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Publications produced by the clearinghouse are reviewed carefully for scientific accuracy, content, and readability.
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NIH Publication No. 99-2897
November 1998
e-text posted: January 1999
