October 2005
Jefferson Scientists Identify Gene Defect Leading to Abnormal Skin Development and Cancer
(Published 10-2-2005) Researchers at Jefferson Medical College and at the Wadsworth Center in New York have identified a gene
defect in mice resulting in a range of abnormalities, from cyclical hair loss and skin cancer to severe problems in normal
skin development. The work may lead to improved treatments for skin injuries, including burns, and might have implications
for diseases such as eczema and psoriasis, as well as certain cancers.
Jefferson Scientists Uncover New Clues to How Crucial Molecular Gatekeepers Work
(Published 10-10-2005) One of the biggest mysteries in molecular biology is exactly how ion channels – tiny protein pores
through which molecules such as calcium and potassium flow in and out of cells – operate. Such channels can be extremely important;
members of the voltage-gated ion channel family are crucial to generating electrical pulses in the brain and heart, carrying
signals in nerves and muscles. When channel function goes awry, the resulting diseases – known as channelopathies, including
epilepsy, a number of cardiomyopathies and cystic fibrosis – can be devastating.
Trauma Surgeon Gary Lindenbaum, M.D., Joins Thomas Jefferson University Hospital
(Published 10-14-2005) Surgeon Gary A. Lindenbaum, M.D., FACS, FCCP, who specializes in trauma and general surgery, has joined
the Department of Surgery of Thomas Jefferson University Hospital, Philadelphia. He has also been named clinical associate
professor of Surgery, Jefferson Medical College of Thomas Jefferson University.