April 2006
Jefferson Researchers Discover that Nanoparticle Shows Promise in Reducing Radiation Side Effects
(Published 4-5-2006) Using transparent zebrafish embryos, researchers at Jefferson Medical College in Philadelphia have shown
that a microscopic nanoparticle can help fend off damage to normal tissue from radiation. The nanoparticle, a soccer ball-shaped,
hollow, carbon-based structure known as a fullerene, acts like an “oxygen sink,” binding to dangerous oxygen radicals produced
by radiation.
Timing of Radiation Treatments for Colon Cancer May Need Adjusting, Jefferson Researchers Say
(Published 4-7-2006) Scientists have unexpectedly discovered that mice with the gene defect that causes colon cancer in humans
can differ from normal mice in how they respond to radiation treatments. The large intestine carrying the gene defect in mice
that received staggered doses of radiation was three to four times more resistant to the radiation than in control mice.
Jefferson Scientists Uncover Lethal Gene Mutation Key to Blocking Cholesterol Processing
(Published 4-18-2006) When Jefferson Medical College researcher Shiu-Ying Ho, Ph.D., and her colleagues first created a mutation
that limited the absorption of lipids and cholesterol into the bloodstream in zebrafish, the possibilities seemed endless.
The discovery boded well for new insights into mechanisms behind lipid and cholesterol processing, and in turn, the potential
development of new cholesterol-controlling drugs.