Techniques for improving the implantation of embryos obtained through IVF include assisted hatching and co-culture. With assisted hatching, a notch is made into the zona pellucida, which is the protein layer surrounding the egg. This aids the escape of the growing embryo which helps in the implantation process.

With co-culture, the culture medium for embryos is enhanced by the presence of another type of cell in an effort to emulate the environment of the fallopian tube. Tubal epithelial cells are one such cell line that are used which may provide embryos with important nutrients or growth factors lacking in the artificial medium.