Thomas Jefferson University Hospital
 
DEPARTMENT OF OBSTETRICS & GYNECOLOGY

Fibroid Research

Goldberg J, Burd I, Price FV, Worthington-Kirsch R. Leiomyosarcoma in a pre-menopausal patient following uterine artery embolization. Am J Obstet Gynecol 2004;191:1733-5.
The first reported uterine sarcoma (cancerous fibroid) in a premenopausal woman following UAE. Given the difficulty in diagnosing leiomyosarcoma and the increasing popularity of uterine artery embolization, in lieu of myomectomy or hysterectomy, which provide a pathologic specimen, an increasing number of leiomyosarcomas will be unavoidably delayed in diagnosis. As other gynecologic problems, including cancer, may co-exist or develop later in the presence of uterine fibroids, a lack of clinical response to a technically successful embolization should alert care-providers that further evaluation and/or therapy is needed.

Mude-Nochumson H, Goldberg J. Fertility-sparing treatment options for women with symptomatic fibroids. Female Patient 2003;28:21-6.
Fertility-sparing Treatment Options for Women With Symptomatic Fibroids

63K pdf file

Goldberg J, Pereira L, Diamond J, Berghella V, Daraï E, Seinera P, Seracchioli R.  Pregnancy outcomes following treatment for fibroids: uterine artery embolization versus laparoscopic myomectomy. Am J Obstet Gynecol 2004;191:18-21.
The first published study comparing pregnancy outcomes in patients with fibroids previously treated with UFE and myomectomy. Pregnancies following UAE had higher rates of preterm delivery (OR 6.2, 95% CI 1.4, 27.7) and malpresentation (OR 4.3, 95% CI 1.0, 20.5) than pregnancies following LM. The risks of postpartum hemorrhage (OR 6.3, 95% CI 0.6, 71.8) and spontaneous abortion (OR 1.7, 95% CI 0.8, 3.9) following UAE were similarly higher than the risks following LM, however, these differences were not statistically significant.
Pregnancy outcomes following treatment for fibromyomata: uterine artery embolization versus laparoscopic myomectomy
234K ppt file

Goldberg J, Pereira L, Mude-Nochumson H. Uterine artery embolization for symptomatic fibroids. OBG Management, April 2003:69-79.
Uterine artery embolization for symptomatic fibroids

229K pdf file

Muffly T, Goldberg J, Goldberg B. Leiomyoma degeneration during pregnancy masquerading as uterine rupture. Female Patient 2003;28:53-4.
Fibroid degeneration during the second trimester of pregnancy in a patient who had previously undergone myomectomy which clinically and radiologically presented as a uterine rupture.

Gopal M, Goldberg J, Klein T, Fossum G. Embolization of uterine arteriovenous malformation followed by a twin pregnancy. Obstet Gynecol 2003;102:696-8.
A large vascular malformation within the uterine wall was successfully embolized. Following this the patient conceived and had an uneventful twin pregnancy.

Yeagley T, Goldberg J, Klein T, Bonn J. Labial necrosis after uterine artery embolization for leiomyomas. Obstet Gynecol 2002;100:881.
The first case report of non-target embolization of the labia minora, which was successfully managed conservatively with pain medications.

Goldberg J, Berghella V, Pereira L. Pregnancy after uterine artery embolization. Obstet Gynecol 2002;100:869-72.
The first comprehensive analysis of pregnancy outcomes following uterine artery embolization (UAE) for uterine fibroids. Higher rates of complications, including preterm delivery (28%), malpresentation/breech (17%), cesarean delivery (58%), and postpartum hemorrhage (13%), followed UAE than in the general population. Following publication of this series, desire for future fertility is now considered a relative contra-indication.

Sultana CJ, Goldberg J, Aizenman L, Chon JK. Vesicouterine fistula after uterine artery embolization: A case report. Am J Obstet Gynecol 2002;187:1726-7.
The first case report of a vesico-uterine fistula and extrusion of a degenerating fibroid into the bladder after UAE, necessitating hysterectomy and partial cystectomy for repair.

Goldberg J. Pregnancy after uterine artery embolization for leiomyomata: The Ontario Multicenter Trial. Obstet Gynecol 2005;106:195-6.
Commentary on this multicenter study

Goldberg J. Uterine artery embolization for adenomyosis: looking at the glass half full. Radiology 2005;236:1111-2.
Commentary. Adenomyosis is a common disease affecting the uterus, which presents with symptoms similar to fibroid disease. Treatment options are limited for symptomatic women. The most treatment with the highest success rate is hysterectomy. In the eighteen women with adenomyosis treated with uterine artery embolization, there was improvement in menorrhagia in 94% of subjects at 6 months. After two years, however, only 56% still had improvement in of menorrhagia. Uterine artery embolization may be appropriate in the subsets of patients with symptomatic adenomyosis desiring future fertility, who have increased surgical risk due to adhesive disease or those absolutely desiring uterine preservation.

Goldberg J, McCrosson S, Kaulback KR. Fibroid degeneration following microwave endometrial ablation. Obstet Gynecol 2005;106:1176-8.
First case report of delayed fibroid degeneration occurring in a series of patients following microwave endometrial ablation (MEA) for abnormal uterine bleeding.

Goldberg J, Boyle K, Choi M, Panchal N. Bowel obstruction following uterine fibroid embolization. Am J Obstet Gynecol 2005;193:892-3.
First case report of an intra-abdominal adhesion caused by UFE leading to bowel entrapment and obstruction. The obstruction was quickly recognized and relieved with laparotomy and lysis of the adhesion, with avoidance of bowel resection.

Goldberg J. Uterine fibroid embolization : A new treatment for uterine fibroids. Female Patient 2006;31:45-50.
A comprehensive review article on UFE.

Goldberg J, Mella MT. Uterine fibroid embolization complicated by non-target labial embolization. Female Patient 2006;31:26-7.
The second case report of this rare complication of UFE, which was managed conservatively. Although the necrotic labial area cosmetically resolved, the patient has a persistent change in labial sensitivity.

Goldberg J, Pereira L. Pregnancy outcomes following uterine fibroid embolization and myomectomy. Current Opin Ob Gyn 2006;18:402-6.

Goldberg J, Cothran S, Bonn J. Pre-myomectomy uterine fibroid embolization for a massively enlarged fibroid uterus. Female Patient 2006;31:1-3.

Goldberg J, Bussard A, McNeil J, Diamond J. Cost and reimbursement for three fibroid treatments: Abdominal hysterectomy, abdominal myomectomy, and uterine fibroid embolization. CVIR 2007; 30:54-8.

Goldberg J. Current thinking on the role of interventional radiology in women’s health . Expert Opin Gyn Obstet 2007;2:621-9.
Expert Review IR in Woman's Health

Myometrial air infiltration following postpartum UAE: Imaging findings
Presented at 36th Global Congress of Minimally Invasive Gynecology, Washingtin, DC, 2007.
187K pdf file

Perceptions of patients desiring fertility of fibroid treatments .
Presented at the ACOG Annual Clinical Meeting in New Orleans, May 2008
1.21 MB ppt file

Perceptions of patients NOT desiring fertility of fibroid treatments.
Presented at the ACOG Annual Clinical Meeting in New Orleans, May 2008
1.84 MB ppt file


Jefferson Medical College students, Michelle Hellman and Dominic Femiano, involved in fibroid research.

 
Jenna Angelo and Michelle Hellman present their fibroid study at the 2008 ACOG Annual Clinical Meeting in New Orleans.


Dr. Jay Goldberg and Dr. Sean McConnell presenting at the 36th Global Congress of Minimally Invasive Gynecology, Washington, DC, 2007.



Jefferson faculty and alumni at the 36th Global Congress of Minimally Invasive Gynecology, Washington, DC, 2007.


Jefferson's Jay Goldberg, Jesica Bromberg, Jolene Seibel-Seamon, and Anne Bussard present their research at the 2nd NIH International Congress of Advances in Uterine Leiomyoma Research in Bethesda, February 2005

 
Anne Bussard and Jay Goldberg present their research at 2nd NIH International Congress of Advances in Uterine Leiomyoma Research on costs and reimbursements for 3 fibroid treatments (myomectomy, hysterectomy, and uterine fibroid embolization).


 Jolene Seibel-Seamon presents her research at 2nd NIH International Congress of Advances in Uterine Leiomyoma Research which evaluated the FDA's MAUDE database and the scientific literature with regard to complications following uterine fibroid embolization

  
Jay Goldberg and Jesica V. Bromberg present their research at the 2nd NIH International Congress of Advances in Uterine Leiomyoma Research on the effect of uterine fibroids on pregnancy outcomes.


Drs. Leo Pereira, Jorge Tolosa, and Jay Goldberg at FIGO's International Congress in Chile.


Dr. Leo Pereira and Jay Goldberg present research at FIGO meeting in Chile.

Drs. Leo Pereira, Jay Goldberg, and Vincenzo Berghella