Dr. Fred Gorstein , is the Jacob and Sophie Rubin Professor and Chairman of the Department of Pathology, Anatomy and Cell Biology at the Jefferson
Medical College of Thomas Jefferson University.
Prior to moving to Philadelphia in 1994, he served as the Chairman of the Department of Pathology at Vanderbilt University.
Dr. Gorstein received his undergraduate education at the University Heights College of New York University and his MD from
NYU in 1955. He completed a residency in internal medicine on the NYU service of Bellevue Hospital in New York City, after
which he joined the Pathology Department of the same institution as a resident and USPHS postdoctoral fellow in Pathology
in the laboratory of Dr. Baruj Benacerraf.
Under the supervision of Dr. Benacerraf and subsequently, Dr. Peter Miescher, Dr. Gorstein investigated the mechanisms of
autoimmune disease and immune platelet destruction. These studies conducted almost a decade prior to the discovery of T and
B cells, demonstrated the importance of lymphocytes in the induction of (auto)immune damage. Subsequently, Dr Gorstein joined
the laboratory of Germ Free Animal Research (NIAID) at NIH where utilizing a germ free system, he and his co-worker, Dr. Bruce
Phillips demonstrated the critical role of a bacterial component in initiating amebic infection in the germ free animal. With
Dr. Bertram Gesner, he demonstrated that autoimmune murine thyroiditis could be transferred with lymphocytes. Dr. Gorstein
has had a long time interest in gynecologic pathology and served as the director of the combined NYU-Bellevue Hospital Service
for several years. In collaborative studies with Drs. Ann Thor, William Rodgers, and Kevin Osteen utilizing cultured endometrial
cells, they demonstrated the role of epithelial-stromal interaction in the regulation of metalloproteinase expression in normal
endometrium and endometriosis. These and other studies have been published in over 80 peer reviewed publications.
Over a period of more than 28 years Dr. Gorstein served as the associate editor and editor and editor in chief of Human Pathology. Doctor Gorstein has had a long term and continuing interest in undergraduate and graduate education. He served as the director
of Residency Training at two institutions and has been a strong advocate for a competency based structure for residency programs
for more than a decade. He estimates that he has participated in the training of more than 250 residents and clinical fellows
in pathology over the past 40 years.
As the chair of Pathology at Vanderbilt University, and more recently at Thomas Jefferson University, he has participated
in intramural and national organizations concerned with health policy issues and medical administration. As the chair of the
College of American Pathologists he was instrumental in establishing the CAP Foundation Scholars Award program. He served
as the president of UAREP (Universities Associated with Research and Education in Pathology), was an officer of the many boards
of many organizations such as the American Registry of Pathology and the council of the Association of Pathology Chairs. He
has been the recipient of distinguished service awards from Vanderbilt University and the Association of Pathology Chairs.
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