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A Randomized Controlled Trial of Intraoperative Celiac Plexus Neurolysis for Patients with Operable (Resectable and Unresectable) Pancreatic and Periampullary Cancer

This study will determine if the addition of an intraoperative ethanol celiac plexus neurolysis (alcohol block) in patients undergoing surgical intervention for pancreatic cancer will result in a decrease in cancer associated pain. Site(s) and/or Type:  Pancreas Stage:

Principal Investigator:  Kennedy, Eugene

Patient Eligibility Preoperative imaging indicates possibility of resectable pancreatic cancer Intraoperative biopsy histologically confirming pancreatic adenocarcinoma Protocol Treatment Double blind randomization to receive either celiac plexus neurolysis with 50% ethanol in saline or a normal saline (0.9%) control injection (placebo) Performed by operating surgeon by injecting 20 ml of either ethanol or saline on each side of the aorta at the level of the celiac axis with a 20 or 22 gauge spinal needle